Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. To update your cookie settings, please visit the Cookie Preference Center for this site. Resistance-conferring mutations can be specific to a particular antibiotic or they can provide protection to multipleoften relateddrugs. Jimma Town has one municipality abattoir and about 140 meat retailers which receive directly slaughter service from the abattoir. The Journal of Global Antimicrobial Resistance (JGAR) is a quarterly online Open Access journal run by an international Editorial Board that focuses on the global spread of antibiotic-resistant microbes. We thank the reviewer for the comment on the English language improvement and our revised manuscript is edited by senior professors. The funders had no role in study design, data collection and analysis, decision to, publish, or preparation of the manuscript.". Antibiotic resistance is a threat to the effective prevention and treatment of an ever-increasing range of infections caused by bacteria, parasites, viruses and fungi. Based on the findings; it is sensible to recommend regular coordinated actions like judicial antibiotic usage and hazard analysis of critical control points from the farm, through the abattoir to the retailer and awareness creation on good hygienic practice and processing of raw meat to minimize or eliminate the risk of infectious agents in general and Campylobacter contamination in particular. In the abattoir, cattle usually inspected before slaughtering and the slaughtered cattle were considered as apparently healthy. You should upload this as a separate file labeled 'Revised Manuscript with Track Changes'. Therefore, our study is not out of this fact and we believe it is very important and respected to show the gaps and identify AMR Campylobacter strains in the region. In addition to their essential role in the clinic, antibiotics are used in a huge array of non-medical applications, from promoting growth in livestock, to preserving building materials from contamination, to treating blight in orchards. The Journal of Global Antimicrobial Resistance (JGAR) is a quarterly online Open Access journal run by an international Editorial Board that focuses on the global spread of antibiotic-resistant microbes. The Prokaryotes: Deltaproteobacteria and Epsilonproteobacteria. It remained as global health concern as the group Campylobacter has zoonotic potential, large range of reservoir hosts, and environmental persistence [1, 2].Campylobacter is the fourth (next to rotavirus, typhoid fever and cryptosporidiosis) leading cause of diarrheal diseases of human with estimated 7.5 million global disability adjusted life years. The new PMC design is here! The annual rainfall ranges between 1138mm and 1690mm [19]. Drug resistance was recorded among isolated thermophilic Campylobacter species for at least one antimicrobial agent in two to seven antimicrobial classes. The article does not have any novelty of data or any molecular characterization of isolates. Related Topic: Prescription Drugs Catalog of Topics. Most classes of antibiotics on the market were discovered in the mid-to-late 20th century. But, as mentioned above, resistance comes at a cost, and a study published in Science Reports of the compensatory evolution of a large conjugative resistance plasmid showed that evolution follows common paths leading to plasmid stabilization and persistence of resistance [6]. Overall, the manuscript requires editing on the grammar at many places to improve the clarity and data presentation. The manuscript has been looked at for minor grammar mistakes and the manuscript suffers from a huge amount of grammatical errors. Previous study conducted in Jimma Zone urban and rural farm animals also documented comparable prevalence (12.7%) of Campylobacter species from cattle fecal samples [15]. International Organization for Standardization. | | Since the 1940s, these drugs have greatly reduced illness and death from infectious diseases. Journal of Global Antimicrobial Resistance Guide for authors Guide for Authors Download Guide for Authors in PDF Aims and scope Types of paper Contact details for submission BEFORE YOU BEGIN Ethics in publishing Studies in humans and animals Informed consent and patient details Conflict of Interest Thank you for taking the time to confirm your preferences. Reviewer #3:accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte accepte. Descriptive statistics was used for calculating percentage and frequency distributions, and odds ratio (OR) was used to evaluate the association of variables at 95%CI and p<0.05 was considered as statistically significant. Abamecha A, Assebe G, Tafa B, Wondafrash B. 21 October 2022 2022 Elsevier Ltd. All rights reserved. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Asmai R, Karraouan B, Es-Soucratti K, En-Nassiri H, Bouchrif B, Karib H, et al. Thank you for visiting nature.com. The sample size was calculated using single population proportion formula [20]. To use PACE, you must first register as a user. b. Centers for Disease Control and Prevention. PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. 2013. Given the importance of antibiotics to modern medicine, and the growing apprehension surrounding the threat of resistance, scientists are studying every aspect of antibiotic resistance. The key goal is to maximize collateral sensitivityor when one drug sensitizes the bacteria to the second drugwhile minimizing cross-resistancewhere resistance to one drug confers resistance to the second drug. Yes Antimicrobial agents play a key role in controlling and curing infectious disease. Campylobacter isolates in the present study were susceptible to Nalidixic acid (86.8%), ciprofloxacin (86.8%), Sulphamethazole (84.2%) and ceftriaxone (78.9%). Read more information on sharing protocols at https://plos.org/protocols?utm_medium=editorial-email&utm_source=authorletters&utm_campaign=protocols. No, Is the Subject Area "Antibiotics" applicable to this article? For a list of acceptable repositories, please see http://journals.plos.org/plosone/s/data-availability#loc-recommended-repositories. Emergence of multidrug-resistant Campylobacter species isolates with a horizontally acquired rRNA methylase, www.who.int/iris/bitstream/10665/80751/1/9789241564601_eng.pdf, www.cdc.gov/DrugResistance/Biggest-Threats.html, https://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols, https://plos.org/protocols?utm_medium=editorial-email&utm_source=authorletters&utm_campaign=protocols, https://journals.plos.org/plosone/s/file?id=wjVg/PLOSOne_formatting_sample_main_body.pdf, http://journals.plos.org/plosone/s/data-availability, http://journals.plos.org/plosone/s/data-availability#loc-recommended-repositories, http://journals.plos.org/plosone/s/data-availability#loc-unacceptable-data-access-restrictions, AMP-10, /CFM-5, CTX-30/, CH-30, CIP-10, DA-10, AMP-10, /CFM-5, CTX-30/, CH-30, C-30, TE-30, AMP-10, CFM-5, CH-30, SXT-25, TE-30, DA-10, AMP-10, /CFM-5, CTX-30, CRO-30/, CH-30, TE-30, NA-30, AMP-10, /CFM-5, CTX-30/, CH-30, TE-30, DA-10, NA-30, modified Cefoperazone Charcoal Deoxycholate Agar, Administration and Control Authority of Ethiopia. In your Data Availability statement, you have not specified where the minimal data set underlying the results described in your manuscript can be found. The predominant thermophilic Campylobacter species isolate in the current study was C. jejuni followed by C. coli and C. lari, respectively. Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data. government site. The British Society for Antimicrobial Chemotherapy is an inter-professional organisation with over 40 years of experience and achievement in antibiotic education, research and leadership. However, limited studies reported the occurrence and susceptibility testing of Campylobacter strains to antimicrobials on humans, food animals and foods of animal origin [1618]. Microbes. They show that resistant bacteria can be re-sensitized by treating with a specifically designed anti-sense oligonucleotide. The finding was in agreement with the result documented in Gambella, Ethiopia [16]. Between 2014 and 2016, there were 700,000 deaths around the world attributed to antibiotic resistance. If there are restrictions on publicly sharing datae.g. Wayne, PA: CLSI: 2015. 1, 2 amr is considered a significant threat to the public health systems not just in developing countries but throughout the world. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Isolation of Campylobacter species from faecal, carcass, knife and hand swabs revealed possible risk of contamination and exposure to Campylobacter infection of those who consume raw meat. You will be subject to the destination website's privacy policy when you follow the link. we define three main ways in which bacterial communities, or subpopulations of communities, can survive exposure to antimicrobials due to interspecies interactions: (1) collective resistance,. It has proven itself a highly effective instrument for protecting susceptible populations from preventable and treatable diseases. 1 Please include the following items when submitting your revised manuscript: If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter. The publishing protocol for Journal of Global Antimicrobial Resistance is to publish new original articles that have been appropriately reviewed by competent academic peers. 2. For more information about our data policy, please see http://journals.plos.org/plosone/s/data-availability. Image credit: doi: 10.1371/journal.pbio.2000631. Faecal samples and carcasses swabs were collected from cattle systematically selected from the annual plan of Jimma Municipal Abattoir in 2019/2020. Other readers may not be benefited by the data. When these have been addressed, youll receive a formal acceptance letter and your manuscript will be scheduled for publication. UK Standards for Microbiology Investigations. e. We thank the reviewer for the comment to use standard strain of Campylobacter. One reason antimicrobial-drug resistance has recently become a concern is its economic impact. | However, higher prevalence of Campylobacter species isolates were reported in studies conducted in Gambella and Gondar, Ethiopia [16, 18]. Turbidity of the broth culture was measured with turbido-meter with in absorbance reading range of 0.08 to 0.1 at 625nm (equivalent to 0.5 McFarland turbidity standards). Thermophilic Campylobacter species are commonly isolated from poultry and livestock species such as cattle, swine, and sheep, but poultry is recognized as the primary source of infection for people [6, 7]. Is the manuscript presented in an intelligible fashion and written in standard English? Open Access, Research Highlights It also serves as a baseline research to study source of contamination, to consider the level of abattoir hygiene and to initiate regular inspection of abattoirs for Campylobacter infection and antimicrobial resistance patterns. The resistance to tetracycline in Campylobacter species might be due to presence of plasmid-encoded tet (O) resistant gene in both C. jejuni and C. coli [38, 39]. 15 We included the importance of our finding in the revised manuscript. The paper described the Isolation, identification and antibiogram profile of thermophilic Campylobacter species from bovine, knives and personnel at Jimma Town abattoir, Ethiopia. Antimicrobial resistance (AMR) is a major global threat to the health of populations, endangering the ability to prevent and cure a wide range of infectious diseases [1-3].Despite being a global issue, there is a disparate distribution of AMR among countries, with more impact on the developing countries [4-6].This higher burden on developing countries could attribute to . No, Is the Subject Area "Methicillin-resistant Staphylococcus aureus" applicable to this article? 6. No, PLOS is a nonprofit 501(c)(3) corporation, #C2354500, based in San Francisco, California, US, Corrections, Expressions of Concern, and Retractions, https://doi.org/10.1371/journal.pbio.2003775, https://doi.org/10.1371/journal.ppat.1005932, https://doi.org/10.1371/journal.pbio.2000631, https://doi.org/10.1371/journal.pbio.1002299, https://doi.org/10.1371/journal.pbio.2001741, https://doi.org/10.1371/journal.pgen.1006674, https://doi.org/10.1371/journal.pbio.1002104, https://doi.org/10.1371/journal.pbio.2001644, https://doi.org/10.1371/journal.pcbi.1005321, https://doi.org/10.1371/journal.pcbi.1004857, https://doi.org/10.1371/journal.pbio.1002552, http://collections.plos.org/open-highlights-antibiotic-resistance, Methicillin-resistant Staphylococcus aureus. Distributed Globally, Antimicrobial Resistance in Campylobacter Species: Mechanisms and Genomic Epidemiology. The global view of campylobacteriosis: report of an expert consultation, Utrecht, Netherlands, 911 July 2012. Ethical approval was obtained from Jimma University College of Agriculture and Veterinary Medicine Minutes of Animal Research Ethics and Review committee. If this link does not appear, there are no attachment files.]. Reeser RJ, Medler RT, Billington SJ, Jost BH, Joens LA. Thermophilic Campylobacter species are common cause of animal and human bacterial diseases with growing resistance to antimicrobials. In a PLOS Biology article, researchers utilized a technique originally developed for identifying novel antifungals [9]. For information about this choice, including consent withdrawal, please see our Privacy Policy. 1. National leaders now have an obligation to move AMR to a higher position in their political agendas. For more information please contact gro.solp@sserpeno. Permission was sought from Jimma Town Municipal Abattoir and informed consent was obtained from individuals providing slaughtering service to take personnel hand and knife swabs. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. And donors should invest generously in such a renewed and reinvigorated Fund. a. After careful consideration, we feel that it has merit but does not fully meet PLOS ONEs publication criteria as it currently stands. This Open Highlight features some of the cutting-edge research from the Open Access corpus on three major areas of focus: the cellular mechanisms of resistance, the evolution and spread of resistance, and techniques for combating resistance. The abattoir gives service for 207,573 people (projected population in 2021) in the town with 50.52km2area. Manioglu et al use high-resolution atomic force microscopy to resolve how polymyxins interact with the bacterial membrane. These plasmids encode the genes necessary for two bacteria to pass the plasmid between them, and they can also encode resistance genes. The susceptibility of Campylobacter to available drugs is tending decreased and continuous assessment of AMR at different sites and regions is essential [13, 14]. Innovation has been extremely slow. We are also thankful to technical staff of School of Veterinary Medicine for their assistance during laboratory works and Jimma University, College of Agriculture and Veterinary Medicine for their facilitation and some funds.". El Baaboua A, El Maadoudi M, Bouyahya A, Kounnoun A, Bougtaib H, Belmehdi O, et al. 2022 Rodolfo Parulan Jr/Getty Images. National Library of Medicine Comments & Opinion Some sentences are not clear and difficult to understand. Each year in the United States, at least 2 million people become infected with bacteria that are resistant to antibiotics and at least 23,000 people die each year as a direct result of these infections. A PLOS Biology paper describes how multi-drug resistant bacteria compensate, finding that their compensatory evolution is distinct from that of bacteria resistant to single drugs alone, due to the interaction between the resistance mutations [5]. However, campylobacteriosis is often asymptomatic and self-limiting, and missed during physical diagnosis. No, Is the Subject Area "Bacterial evolution" applicable to this article? A marked-up copy of your manuscript that highlights changes made to the original version. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page. 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